HCID 15512801, compound → HCID 66845791, compound

HRID 386678Notes

Reaction equation

HRID 386678 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:24])[CH3:23])=[CH:17][C:12]=3[C:13](=[O:16])[C:14]=2[OH:15])=[CH:5][CH:4]=1>C(Cl)(Cl)Cl.CO>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[O:10][C:11]3[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:24])[CH3:23])=[CH:17][C:12]=3[C:13](=[O:16])[C:14]=2[O:15][CH2:9][C:6]2[CH:7]=[CH:8][CH:3]=[CH:4][CH:5]=2)=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 15512801HCID 15512801, compound

Product 1

HCID 66845791HCID 66845791, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Prepared analogously to Example 5d) starting from 2-(4-methoxyphenyl)-3-hydroxy-6-acetamido-4H-1-benzopyran-4-one. Yield: 95%; TLC (9/1 Chloroform/Methanol) Rf: 0.51; 1H-NMR (d6-DMSO): 10.31 (s broad, 1H), 8.40 (d, 1H), 8.02 (m, 3H), 7.70 (d, 1H), 7.32 (m, 5H), 7.11 (d, 2H), 5.08 (s, 2H), 3.86 (s, H), 2.11 (s, 3H).

Workup

  1. customPrepared analogously to Example 5d)

Sources & evidence

ORD record
ord-caab3d7d199d42e58588361942af339e
Source dataset
uspto-grants-2013_02
Patent number
US08372866B2

Reaction notes

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