2-(benzo[1,3]dioxol-5-yl)-3-hydroxy-6-acetamido-4H-1-benzopyran-4-one → 2-(benzo[1,3]dioxol-5-yl)-3-benzyloxy-6-acetamido-4H-1-benzopyran-4-one

HRID 386679Notes

Reaction equation

HRID 386679 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[O:11][C:12]4[CH:21]=[CH:20][C:19]([NH:22][C:23](=[O:25])[CH3:24])=[CH:18][C:13]=4[C:14](=[O:17])[C:15]=3[OH:16])=[CH:9][C:4]=2[O:3][CH2:2]1>C(Cl)(Cl)Cl.CO>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[O:11][C:12]4[CH:21]=[CH:20][C:19]([NH:22][C:23](=[O:25])[CH3:24])=[CH:18][C:13]=4[C:14](=[O:17])[C:15]=3[O:16][CH2:10][C:8]3[CH:9]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 1

HCID 99497772-(benzo[1,3]dioxol-5-yl)-3-hydroxy-6-acetamido-4H-1-benzopyran-4-one

Product 1

HCID 668451092-(benzo[1,3]dioxol-5-yl)-3-benzyloxy-6-acetamido-4H-1-benzopyran-4-oneYield 85%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Prepared analogously to Example 5d) starting from 2-(benzo[1,3]dioxol-5-yl)-3-hydroxy-6-acetamido-4H-1-benzopyran-4-one. Yield: 85%; TLC (9/1 Chloroform/Methanol) Rf: 0.57.

Workup

  1. customPrepared analogously to Example 5d)

Sources & evidence

ORD record
ord-f080046ddf6e4b6692436433d3baeb97
Source dataset
uspto-grants-2013_02
Patent number
US08372866B2

Reaction notes

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