3-(2-tert-Butoxycarbonyl-ethylsulfamoyl)-benzoic acid → HCID 178451121, compound

HRID 386692Notes

Reaction equation

HRID 386692 reaction equation
[C:1]([O:5][C:6]([CH2:8][CH2:9][NH:10][S:11]([C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=1)[C:17]([OH:19])=O)(=[O:13])=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[NH:24]1[C:28]2([CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH2:27][NH:26]/[C:25]/1=[N:34]\[C:35]([C:37]1[C:42]([NH2:43])=[N:41][C:40]([NH2:44])=[C:39]([Cl:45])[N:38]=1)=[O:36]>>[C:1]([O:5][C:6](=[O:7])[CH2:8][CH2:9][NH:10][S:11]([C:14]1[CH:22]=[CH:21][CH:20]=[C:16]([C:17]([N:31]2[CH2:32][CH2:33][C:28]3([NH:24]/[C:25](=[N:34]/[C:35]([C:37]4[C:42]([NH2:43])=[N:41][C:40]([NH2:44])=[C:39]([Cl:45])[N:38]=4)=[O:36])/[NH:26][CH2:27]3)[CH2:29][CH2:30]2)=[O:19])[CH:15]=1)(=[O:12])=[O:13])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 667975563-(2-tert-Butoxycarbonyl-ethylsulfamoyl)-benzoic acidHCID 178479156HCID 178479156, compound

Product 1

HCID 178451121HCID 178451121, compound

Procedure

The title compound was prepared from 3-(2-tert-butoxycarbonyl-ethylsulfamoyl)-benzoic acid (Int. AD) and 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid [1,3,8-triaza-spiro[4.5]dec-(2E)-ylidene]-amide hydrochloride in an analogous method to Example 1; LC-MS Rt 0.93 mins; 636.3 [M+H]+, Method 2minLC_v003.

Sources & evidence

ORD record
ord-df89a7930aea4a56b459e5ffae1a35f8
Source dataset
uspto-grants-2013_02
Patent number
US08372845B2

Reaction notes

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