HRID386692

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)CCNS(=O)(=O)c1cccc(C(=O)O)c1

HCID66797556

未命名化合物

$结构：Cl.Nc1nc(N)c(C(=O)/N=C2\NCC3(CCNCC3)N2)nc1Cl$

HCID178479156

未命名化合物

PRODUCTS

生成物

$结构：CC(C)(C)OC(=O)CCNS(=O)(=O)c1cccc(C(=O)N2CCC3(CC2)CN/C(=N\C(=O)c2nc(Cl)c(N)nc2N)N3)c1$

HCID178451121

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 3-(2-tert-butoxycarbonyl-ethylsulfamoyl)-benzoic acid (Int. AD) and 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid [1,3,8-triaza-spiro[4.5]dec-(2E)-ylidene]-amide hydrochloride in an analogous method to Example 1; LC-MS Rt 0.93 mins; 636.3 [M+H]+, Method 2minLC_v003.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-df89a7930aea4a56b459e5ffae1a35f8
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08372845B2
来源说明: uspto-grants-2013_02

反应 SMILES

[C:1]([O:5][C:6]([CH2:8][CH2:9][NH:10][S:11]([C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=1)[C:17]([OH:19])=O)(=[O:13])=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[NH:24]1[C:28]2([CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH2:27][NH:26]/[C:25]/1=[N:34]\[C:35]([C:37]1[C:42]([NH2:43])=[N:41][C:40]([NH2:44])=[C:39]([Cl:45])[N:38]=1)=[O:36]>>[C:1]([O:5][C:6](=[O:7])[CH2:8][CH2:9][NH:10][S:11]([C:14]1[CH:22]=[CH:21][CH:20]=[C:16]([C:17]([N:31]2[CH2:32][CH2:33][C:28]3([NH:24]/[C:25](=[N:34]/[C:35]([C:37]4[C:42]([NH2:43])=[N:41][C:40]([NH2:44])=[C:39]([Cl:45])[N:38]=4)=[O:36])/[NH:26][CH2:27]3)[CH2:29][CH2:30]2)=[O:19])[CH:15]=1)(=[O:12])=[O:13])([CH3:2])([CH3:3])[CH3:4]