HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 386703Generated: November 2, 2026
Trifluoroacetic acid → 3-Amino-propionic acid dipropylcarbamoylmethyl ester trifluoroacetate
https://huagongshe.com/reaction/386703
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Isopropyl Acetate | HCID 7915 | — |
| Reactant | 2-(Dipropylamino)-2-oxoethyl 3-(((benzyloxy)carbonyl)amino)propanoate | HCID 66797902 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 3-Amino-propionic acid dipropylcarbamoylmethyl ester trifluoroacetate | HCID 86663346 | — |
Reaction Steps
A solution of 3-benzyloxycarbonylamino-propionic acid dipropylcarbamoylmethyl ester in isopropyl acetate (33.2 g, 91.0 mmol in 129.9 g total mass of solution) was treated with TFA (7.05 ml, 92.0 mmol) while the internal temperature was maintained at 20° C., followed by 10% Pd/C (3.3 g, 50% wet) and stirred under an atmosphere of H2 (3 atm) for 3.5 h to afford 3-amino-propionic acid dipropylcarbamoylmethyl ester trifluoroacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08372845B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-7f00752dff8a47c89866a3cda0794182 |
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| Source note | uspto-grants-2013_02 |
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