反应详情

A solution of 4-methyl-3-nitrobenzoylchloride (5.5 g) in dioxane (30 mL) was added dropwise to a solution of water (30 mL), dioxane (30 mL) and sodium borohydride (2.5 g) under ice cooling. The reaction solution was refluxed for one hour, and after cooling, the solution was filtered through Celite. Water was added to the filtrate, the mixture was extracted with ethyl acetate, and the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain a crude product of (4-methyl-3-nitrophenyl)methanol (4 g).

1. temperatureThe reaction solution was refluxed for one hour
2. temperatureafter cooling
3. filtrationthe solution was filtered through Celite
4. additionWater was added to the filtrate
5. extractionthe mixture was extracted with ethyl acetate
6. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
7. distillationThe solvent was distilled off under reduced pressure