N-bromobutanimide → HCID 86643374, compound

Participants

Reaction Steps

A solution of 5-(3,5-dichlorophenyl)-3-(4-methyl-3-nitrophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (1.9 g), N-bromosuccinimide (0.9 g) and 2,2′-azobisisobutylonitrile (0.1 g) in dichloroethane was heated to reflux for 3 hours. The reaction solution was washed with water, and the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue was then purified by silica gel chromatography to yield 3-[4-(bromomethyl)-3-nitrophenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (1.2 g).

Provenance & Evidence