2-Pyridinemethanamine → HCID 68517676, compound

Participants

Reaction Steps

To a solution of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]benzaldehyde (0.30 g), 2-aminomethylpyridine (0.09 g) and trimethylsilylcyanide (0.08 g) in tetrahydrofuran (5 mL), lithium perchlorate (0.8 g) was added, and the mixture was then stirred for one hour at room temperature. After the reaction mixture was diluted with t-butylmethylether, the solution was washed with water and saturated brine. The organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue was then purified by silica gel chromatography to obtain {4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]phenyl}[(pyridin-2-ylmethyl)amino]acetonitrile (0.15 g).

Provenance & Evidence