Dimethylformamide → HCID 66850876, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl N-{[1-(2-bromobenzyl)-4-hydroxy-2-oxo-6-(1,3-thiazol-4-ylcarbonyl)-2,5,6,7-tetrahydro-1H-pyrrolo[3,4-b]pyridin-3-yl]carbonyl}glycinate (0.2 g, 0.34 mmol, prepared in similar fashion to Intermediate 5) was dissolved in DMF (4 mL) and water (0.04 mL). Zn(CN)2 (40 mg, 0.34 mmol), dppf (24.8 mg, 0.045 mmol) and Pd2(dba)3 (17 mg, 0.019 mmol) were added and the flask was evacuated and backfilled with nitrogen 3 times. The mixture was heated at 110° C. overnight. The reaction was cooled and partitioned between EtOAc and 2 M HCl, dried (Na2SO4), filtered and concentrated. The residue was purified by flash chromatography on silica gel gradient eluted with 0-100% EtOAc in hexane affording the product.

Provenance & Evidence