HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 386780Generated: October 30, 2026
Methyl iodide → 4-(5-Isopropoxy-2-methyl-4-nitro-phenyl)-1-methyl-pyridinium iodide
https://huagongshe.com/reaction/386780
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 5-Methyl-2-isopropyloxy-4-(pyridine-4-YL)-nitrobenzene | HCID 59764545 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(5-Isopropoxy-2-methyl-4-nitro-phenyl)-1-methyl-pyridinium iodide | HCID 67071170 | — |
Reaction Steps
4-(5-Isopropoxy-2-methyl-4-nitro-phenyl)-pyridine (Example 7, Step 1, 217 mg, 0.797 mmol) is dissolved in anhydrous THF (9 mL). Iodomethane (0.10 mL, 1.61 mmol, 2 equiv.) is added and the reaction is stirred at 40° C. in a sealed tube for 2 days. The volatiles are removed under vacuum generating 4-(5-Isopropoxy-2-methyl-4-nitro-phenyl)-1-methyl-pyridinium iodide as a brown solid: ESMS m/z 287.1 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08372858B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-ac349520dfdf44d2b27e690b74776628 |
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| Source note | uspto-grants-2013_02 |
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