Hydrochloric Acid → HCID 59253266, compound

Participants

Reaction Steps

To a solution of methyl 2-{[1-(cyclopropylmethyl)-2-(2,2-dimethyl-propyl)-1H-benzoimidazol-5-yl]sulfonyl}-2-methylpropanoate (1.65 g, 4.06 mmol) in methanol (7.5 mL) and THF (7.5 mL) is added 2N aqueous NaOH solution at room temperature. The reaction is stirred for 3 h, then acidified with 2N aqueous HCl solution to pH 4 and concentrated under reduced pressure. The residue is partitioned between water (75 mL) and DCM (75 mL). The acidic aqueous layer is extracted with DCM (50 mL×2) and the combined organic extracts are dried over Na2SO4, filtered and the filtrated is concentrated under reduced pressure to afford 1.31 g of 2-{[1-(cyclopropylmethyl)-2-(2,2-dimethyl-propyl)-1H-benzoimidazol-5-yl]sulfonyl}-2-methylpropanoic acid. Yield: 82%, ES-MS: 393 [M+H]

Provenance & Evidence