HCID 60135717, compound → HCID 60135714, compound

Participants

Reaction Steps

6-[4-(2-Benzyloxy-acetoxy)-phenoxy]-hexanoic acid methyl ester 19 (15 grams, 38.86 mmol) is dissolved in methanol (100 ml) in a pressure vessel, palladium on carbon (50% wet, 5%, 15 grams) added and the mixture stirred under an atmosphere of hydrogen (4 Kg) for 48 hours. The catalyst is removed by aeration and distilled off the methanol. The crude can be purified by column chromatography on silica gel using chloroform as eluant.

Provenance & Evidence