HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 38694Generated: October 29, 2026
Lithium Hydroxide → (6-Methoxy-2'-phenoxymethyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid
https://huagongshe.com/reaction/38694
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | (6-Methoxy-2'-phenoxymethyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester | HCID 67429230 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (6-Methoxy-2'-phenoxymethyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid | HCID 45280297 | — |
Reaction Steps
To a solution of (6-methoxy-2′-phenoxymethyl-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester (0.24 mmol) in 1,4-dioxane and H2O was added lithium hydroxide (a spatula tip), and the reaction was stirred at 55° C. overnight. After work-up, the crude material was purified by preparative HPLC to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08524748B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-4ec1fee5261240949706f6ff515f0e8d |
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| Source note | uspto-grants-2013_09 |
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