1-(2,4-Xylyl)piperazine → 1-(3-(1-tert-butyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine

Participants

Role	Name	HCID	Charge
Reactant	1-(2,4-Xylyl)piperazine	HCID 70544	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	Sodium triacetoxyborohydride	HCID 5049666	—
Reactant	3-(1-tert-butyl-5-p-tolyl-1H-pyrazol-3-yl)propanal	HCID 86639917	—
Product	1-(3-(1-tert-butyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine	HCID 25065262	—

Reaction Steps

88 mg (82%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-tert-butyl-5-p-tolyl-1H-pyrazol-3-yl)propanal (60 mg, 0.222 mmol), 1-(2,4-dimethylphenyl)piperazine (42 mg, 0.222 mmol), DIPEA (0.06 mL, 0.333 mmol) and NaBH(OAc)3 (141 mg, 0.666 mmol).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08372844B2
Source dataset	uspto-grants-2013_02
ORD ID	ord-4f9d966a701f44e78ac2e5af53569cba
Source note	uspto-grants-2013_02