1-(2,4-Xylyl)piperazine → 1-(2,4-dimethylphenyl)-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine

Participants

Role	Name	HCID	Charge
Reactant	1-(2,4-Xylyl)piperazine	HCID 70544	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	Sodium triacetoxyborohydride	HCID 5049666	—
Reactant	3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propanal	HCID 86639918	—
Product	1-(2,4-dimethylphenyl)-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine	HCID 25065659	—

Reaction Steps

113 mg (82%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propanal (80 mg, 0.276 mmol), 1-(2,4-dimethylphenyl)piperazine (53 mg, 0.276 mmol), DIPEA (0.072 mL, 0.414 mmol) and NaBH(OAc)3 (175 mg, 0.828 mmol).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08372844B2
Source dataset	uspto-grants-2013_02
ORD ID	ord-012071c9e55340adad600d5b3e1f8b4d
Source note	uspto-grants-2013_02