HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 4-(3-(5-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-2-methyl-1-m-tolylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Methyl-1-(m-tolyl)piperazine | HCID 2723804 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 3-(5-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)propanal | HCID 86639920 | — |
| Product | 4-(3-(5-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-2-methyl-1-m-tolylpiperazine | HCID 25066505 | — |
Reaction Steps
120 mg (89%) of target compound was obtained by using a method same as in Example 1 by using 3-(5-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-yl)propanal (80 mg, 0.261 mmol), 2-methyl-1-m-tolylpiperazine (50 mg, 0.261 mmol), DIPEA (0.068 mL, 0.392 mmol) and NaBH(OAc)3 (166 mg, 0.783 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08372844B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-12e048675cb3402ea538ee4793c399a0 |
| Source note | uspto-grants-2013_02 |