Sodium Hydroxide → (2'-Hydroxymethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

Participants

Reaction Steps

To (2′-acetoxymethyl-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester (0.54 mmol) in THF (1 mL) and MeOH (0.8 mL) was added 1N aqueous NaOH (0.6 mL), and the reaction was stirred at room temperature for 1.5 hours. The mixture was partitioned between CH2Cl2 and aqueous HCl, and the aqueous layer was extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered, and concentrated to give the title compound.

Provenance & Evidence