HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1-(4-chlorophenyl)-4-(3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(4-Chlorophenyl)piperazine | HCID 97478 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)-propanal | HCID 86639922 | — |
| Product | 1-(4-chlorophenyl)-4-(3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)piperazine | HCID 25066914 | — |
Reaction Steps
77 mg (65%) of target compound was obtained by using a method same as in Example 1 by using 3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)-propanal (70 mg, 0.225 mmol), 1-(4-chlorophenyl)piperazine (61 mg, 0.225 mmol), DIPEA (0.059 mL, 0.338 mmol) and NaBH(OAc)3 (143 mg, 0.675 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08372844B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-4737dd8c1a734328b37f97cf49e1e83b |
| Source note | uspto-grants-2013_02 |