1-(2,4-Xylyl)piperazine → 1-(3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine

Participants

Role	Name	HCID	Charge
Reactant	1-(2,4-Xylyl)piperazine	HCID 70544	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	Sodium triacetoxyborohydride	HCID 5049666	—
Reactant	3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)-propanal	HCID 86639924	—
Product	1-(3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine	HCID 25064225	—

Reaction Steps

96 mg (70%) of target compound was obtained by using a method same as in Example 1 by using 3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)-propanal (80 mg, 0.272 mmol), 1-(2,4-dimethylphenyl)piperazine (52 mg, 0.272 mmol), DIPEA (0.071 mL, 0.408 mmol) and NaBH(OAc)3 (173 mg, 0.816 mmol).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08372844B2
Source dataset	uspto-grants-2013_02
ORD ID	ord-6e947b55261f4df0892debe68ef385a5
Source note	uspto-grants-2013_02