1-(2,3-Xylyl)piperazine → 1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-(2,3-dimethylphenyl)piperazine

Participants

Role	Name	HCID	Charge
Reactant	1-(2,3-Xylyl)piperazine	HCID 70541	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	Sodium triacetoxyborohydride	HCID 5049666	—
Reactant	3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propanal	HCID 86639925	—
Product	1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-(2,3-dimethylphenyl)piperazine	HCID 25064651	—

Reaction Steps

86 mg (96%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propanal (50 mg, 0.191 mmol), 1-(2,3-dimethylphenyl)piperazine (36 mg, 0.191 mmol), DIPEA (0.050 mL, 0.287 mmol) and NaBH(OAc)3 (121 mg, 0.573 mmol).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08372844B2
Source dataset	uspto-grants-2013_02
ORD ID	ord-b56d16a4b3254f939b0f3512b8826c7a
Source note	uspto-grants-2013_02