反应详情

Three grams of 8-(2-methoxy-4-benzyloxy-phenyl)-2-benzyloxypurine are dissolved in 100 ml of ethanol and hydrogenated in the presence of 1 gm of 20% palladium/charcoal for two hours at 50° C. with hydrogen at 5 bar. The catalyst is filtered off and washed with hot ethanol. The filtrates are evaporated, and the residue is triturated with methylene chloride. The solid product obtained is stirred with 30 ml of 2N sodium hydroxide solution. The solution is filtered, and the filtrate is acidified with glacial acetic acid. The precipitate formed is separated from the solution by centrifuging and purified by triturating with acetone. The product contains 1 mol of water of crystallization.

1. filtrationThe catalyst is filtered off
2. washwashed with hot ethanol
3. customThe filtrates are evaporated
4. customthe residue is triturated with methylene chloride
5. customThe solid product obtained
6. filtrationThe solution is filtered
7. customThe precipitate formed
8. customis separated from the solution by centrifuging
9. custompurified
10. customby triturating with acetone