HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → 1-phenyl-4-(3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propanal | HCID 86639931 | — |
| Product | 1-phenyl-4-(3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propyl)piperazine | HCID 68556040 | — |
Reaction Steps
96 mg (69%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propanal (80 mg, 0.330 mmol), 1-phenylpiperazine (0.050 mL, 0.330 mmol), DIPEA (0.090 mL, 0.495 mmol) and NaBH(OAc)3 (210 mg, 0.990 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08372844B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-243929d07c72448b97aa0d12c44e13fa |
| Source note | uspto-grants-2013_02 |