反应详情

温度

85 °C

2-Methoxy-5-trifluoromethylphenyl isocyanate (274.3 g) is dissolved in acetonitrile (1 l), then 2-bromo-6-fluoroaniline (200 g) is added and rinsed out with acetonitrile (50 ml). The resulting clear solution is stirred under reflux (ca. 85° C.) for 38 h, then concentrated in vacuo at 40° C. to a viscous magma. This is filtered off with suction, washed with acetonitrile (260 ml, cooled to 0-5° C.) and dried overnight at 45° C. in the VDO using entraining nitrogen. A total of 424.3 g of N-(2-bromo-6-fluorophenyl)-N′-[2-methoxy-5-(trifluoromethyl)phenyl]urea are obtained as a solid, corresponding to 99.2% of theory.

1. washrinsed out with acetonitrile (50 ml)
2. concentrationconcentrated in vacuo at 40° C. to a viscous magma
3. filtrationThis is filtered off with suction
4. washwashed with acetonitrile (260 ml, cooled to 0-5° C.)
5. customdried overnight at 45° C. in the VDO