反应详情

温度

82 °C

2-Methoxy-5-trifluoromethylphenyl isocyanate (1057.8 g) is dissolved in acetonitrile (4240 ml), then 2-fluoroaniline (540.8 g) is added thereto and the mixture is rinsed in with acetonitrile (50 ml). The resulting clear solution is stirred under reflux (ca. 82° C.) for 4 h, then seeded at ca. 78° C. and stirred for ca. 15 min. The suspension is cooled to 0° C., and the product is filtered off with suction and washed with acetonitrile (950 ml, cooled to 0-5° C.). The product is dried overnight at 45° C. in a vacuum drying oven using entraining nitrogen. A total of 1380.8 g of N-(2-fluorophenyl)-N′-[2-methoxy-5-(trifluoromethyl)phenyl]urea are obtained as a solid, corresponding to 86.4% of theory.

1. washthe mixture is rinsed in with acetonitrile (50 ml)
2. customseeded at ca. 78° C.
3. stirringstirred for ca. 15 min
4. temperatureThe suspension is cooled to 0° C.
5. filtrationthe product is filtered off with suction
6. washwashed with acetonitrile (950 ml, cooled to 0-5° C.)
7. customThe product is dried overnight at 45° C. in a vacuum
8. customdrying oven