Potassium Carbonate → HCID 59332798, compound

Participants

Reaction Conditions

Reaction Steps

The intermediate 1-(1,1-dimethylethyl) 7-methyl 5-bromo-3-(1,1-dioxido-4-thiepanyl)-1H-indole-1,7-dicarboxylate (88 mg, 0.18 mmol), PdCl2(dppf) (13 mg, 0.109 mmol), K2CO3 (75 mg, 0.54 mmol), and PhB(OH)2 (33 mg, 0.27 mmol) were mixed together and the taken up in dioxane/H2O (3/1, 2 mL). The reaction was heated in a microwave oven at 120° C. for 10 minutes. The mixture was diluted with AcOEt, washed with 1N HCl, H2O and brine, dried over MgSO4, and concentrated. The residue was dissolved in MeOH (5 mL). 6N NaOH (1 mL) was added and the mixture was stirred at room temperature overnight. The reaction was diluted with AcOEt, washed with 1N HCl, H2O, dried over MgSO4, and then concentrated, giving the title compound. LC/MS: m/z 384.1 (M+H), Rt 1.87 min.

Provenance & Evidence