HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 59332646, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | Ammonia methanol | HCID 21705897 | — |
| Reactant | HCID 59332629 | HCID 59332629 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59332646 | HCID 59332646 | 65% |
Reaction Steps
To a solution of 5-bromo-3-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methyl]-1H-indole-7-carboxylic acid (1.2 g, 3.22 mmol) in CH2Cl2 (100 mL) was added Et3N (650 mg, 6.44 mmol), TBTU (2.1 g, 6.44 mmol), and NH3/MeOH (10 mL). The mixture was stirred for 2 hours at room temperature. The reaction solution was washed with water, and the organic phase was dried (MgSO4), concentrated, and purified by column chromatography on silica gel, giving 770 mg (65%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08372875B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-747eea31936c4b5d9fd9021795999dc8 |
| Source note | uspto-grants-2013_02 |