Lithium Hydroxide → HCID 59332773, compound

Participants

Reaction Steps

A mixture of ethyl 5-bromo-3-((1,1-dioxo-tetrahydro-2H-thiopyran-3-yl)methyl)-1H-indole-7-carboxylate (1.42 g, 0.034 mol) and LiOH (3.4 mL, 3 M) in MeOH (50 mL) was heated at reflux for one hour. The solvent was evaporated, and the mixture was acidified with 1N HCl and extracted with EtOAc (3×100 mL). The organic layer was dried, filtered and concentrated under reduced pressure, 1.30 (98.5%) of the title compound, which was carried on as is for the next step without further purification.

Provenance & Evidence