HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-(5-{[(1,1-Dimethylethyl)amino]sulfonyl}-2-thienyl)-1H-indole-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Bromo-N-tert-butylthiophene-2-sulfonamide | HCID 2757187 | — |
| Reactant | 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-7-carboxamide | HCID 59332740 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 5-(5-{[(1,1-Dimethylethyl)amino]sulfonyl}-2-thienyl)-1H-indole-7-carboxamide | HCID 59332602 | 59.1% |
Reaction Steps
5-bromo-N-(1,1-dimethylethyl)-2-thiophenesulfonamide (828 mg, 2.78 mmol) and 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-7-carboxamide (4.17 mmol, 1.5 eq), potassium carbonate (1.524 g) and Pd(PPh3)4 (50 mg) were heated in Microwave at 150 degree for 15 mins after degassing for 5 mins with argon. The reaction solution was filtered off palladium with PL-thiol MP SPE cartridge, concentrated and purified by HPLC with CH3CN/H2O/0.1% TFA to give 620 mg title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08372875B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-6d456d43150f4ac3ba5317adbf9ce26e |
| Source note | uspto-grants-2013_02 |