참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 5-Bromothiophene-2-sulfonyl chloride | HCID 2733924 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | 1-[(5-Bromo-2-thienyl)sulfonyl]pyrrolidine | HCID 893939 | — |
반응 단계
5-Bromo-2-thiophenesulfonyl chloride (523 mg, 2 mmol) was dissolved in dichloromethane (20 mL). Pyrrolidine (213 mg, 3 mmol) and potassium carbonate (829 mg, 6 mmol,) are added, and the mixture was stirred at 23° C. for 1 h. After tlc (30% ethyl acetate in hexanes) indicated that the reaction had gone to completion, brine was added and the mixture was extracted with dichloromethane. The combined organic layers were dried (Na2SO4), filtered, and concentrated. The crude product was purified by isco combiflash, eluting with 0-50% ethyl acetate in hexanes (40 g column), giving the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08372875B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_02 |
|---|
| ORD ID | ord-dbf764413dff48a98a421d388020c9f2 |
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| 출처 메모 | uspto-grants-2013_02 |
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