HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 1-(o-Tolyl)-5-phenyl-triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Phenylacetylene | HCID 10821 | — |
| Reactant | 1-Azido-4-methylbenzene | HCID 137430 | — |
| Catalyst | Chlororuthenium(1+) 1,2,3,4,5-pentamethylcyclopenta-2,4-dien-1-ide--triphenylphosphane (1/1/2) | HCID 71310463 | — |
| Product | 1-(o-Tolyl)-5-phenyl-triazole | HCID 68432633 | 51% |
Reaction Steps
4-Tolyl azide (133 mg, 1 mmol), phenylacetylene (113 mg, 1.1 mmol), Cp*RuCl(PPh3)2 (16 mg, 0.02 mmol, 2 mol %). Solvent: THF, 10 mL, 60° C., 6 hours. Slightly yellow product obtained in 51% yield (120 mg). ESI-MS: m/z 236, [M+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08372986B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-9d4774a15f234d5e8296945ef84477d4 |
| Source note | uspto-grants-2013_02 |