反应详情

Neat SOCl2 (25.7 g, 216.7 mmol) was added dropwise to a −60° C. solution of MeOH (100 mL). Upon completion of the addition, 3-(4-chlorophenyl)propanoic acid (10.0 g, 54.1 mmol) was added in several portions. Upon completion of the addition, the cooling bath was removed, and the reaction mixture was slowly warmed to room temperature and stirred overnight. The reaction was then concentrated to dryness, and the resulting residue was dissolved in DCM (100 mL), washed with saturated NaHCO3, dried (MgSO4), filtered, and concentrated to give methyl 3-(4-chlorophenyl)propanoate as an oil (10.48 g, 97%).

1. additionwas added in several portions
2. additionUpon completion of the addition
3. customthe cooling bath was removed
4. concentrationThe reaction was then concentrated to dryness
5. dissolutionthe resulting residue was dissolved in DCM (100 mL)
6. washwashed with saturated NaHCO3
7. dry with materialdried (MgSO4)
8. filtrationfiltered
9. concentrationconcentrated