Dichloromethane → HCID 68757503, compound

Participants

Reaction Steps

TFA (1 mL) was added to tert-butyl 4-(5-cyano-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)piperazine-1-carboxylate (0.158 g, 0.352 mmol) in DCM (5 mL) and stirred at room temperature for 1 hour. The reaction was then concentrated to dryness and dried under vacuum for 3 hours. TFA (1.1 mL, 14.7 mmol) was added, and the mixture was heated at 65° C. for 2 hours. The reaction was concentrated to dryness. The resulting residue was dissolved in DCM (3 mL), and HCl in ether (2 mL, 2M) and ether (5 mL) were added. The resulting solid was collected by filtration to give 4-(piperazin-1-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile dihydrochloride (0.091 g, 70%). MS APCI (+) m/z 229.1 detected.

Provenance & Evidence