Dichloromethane → HCID 68758725, compound

Participants

Reaction Steps

TFA (0.5 mL) was added to a solution of tert-butyl 4-(5-bromo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)piperazine-1-carboxylate (0.10 g, 0.20 mmol, see Example 1) in DCM (2 mL) and stirred at room temperature for 1 hour. The reaction mixture was then concentrated to dryness. The resulting residue was dissolved in TFA (3.067 mL, 39.81 mmol) and heated at 60° C. for 3 hours. The reaction was concentrated to dryness. The resulting residue was dissolved in DCM (0.5 mL), and HCl in ether (2 mL, 2N) was added. The resulting solid was collected by filtration to give 5-bromo-4-(piperazin-1-yl)-1H-pyrazolo[3,4-b]pyridine dihydrochloride (0.050 g, 70%). MS APCI (+) m/z 282.0 detected.

Provenance & Evidence