反应详情

110 mg of N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)isoindoline-4-carboxamide are dissolved in 8 cm3 of ether at a temperature close to 20° C. 0.5 cm3 of a 4M solution of hydrochloric acid in dioxane is added while stirring under argon. The reaction mixture precipitates. The precipitate is filtered under a slight vacuum, washed with 2 lots of 5 cm3 of ethyl ether then dried in a dessicator for 2 h. 80 mg of N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)isoindoline-4-carboxamide hydrochloride (1:1) is obtained in the form of a white solid.

1. customclose to 20° C
2. customThe reaction mixture precipitates
3. filtrationThe precipitate is filtered under a slight vacuum
4. washwashed with 2 lots of 5 cm3 of ethyl ether
5. customthen dried in a dessicator for 2 h