反应详情

38 mg of N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide are dissolved in 8 cm3 of ethyl ether at a temperature close to 20° C. 0.2 cm3 of a 4M hydrochloric acid solution in dioxane is added while stirring under argon. The reaction mixture precipitates. The stirring is stopped in order to remove the supernatant, then 5 cm3 of ethyl ether are again added. This operation is carried out 3 times. The last suspension is then concentrated under reduced pressure (5 kPa). 26 mg of N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride (1:1) are obtained in the form of a white solid.

1. customclose to 20° C
2. customThe reaction mixture precipitates
3. customto remove the supernatant
4. addition5 cm3 of ethyl ether are again added
5. concentrationThe last suspension is then concentrated under reduced pressure (5 kPa)