Diisopropylethylamine → HCID 25206445, compound

Participants

Reaction Steps

Poured into a suspension of 242 mg of (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)butan-2-ol hydrochloride (2:1), 104 mg of 2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid, 8 mg of hydroxybenzotriazole, 99 mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride in 7 cm3 of dichloromethane is 0.28 cm3 of N,N-diisopropylethylamine at a temperature close to 20° C. The reaction mixture is kept stirring for 20 h at a temperature close to 20° C. The suspension obtained is filtered and the precipitate is washed 3 times with 5 cm3 of ethyl ether, then dried under vacuum. 79 mg of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-methoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide are obtained in the form of a white powder.

Provenance & Evidence