反应详情

8.6 g of 7-nitro-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxylate, 10 cm3 of methanol and 28 mg of 10% (dry basis) palladium-on-carbon are stirred under 2 bar of hydrogen in an autoclave for 2 h 20 min at a temperature of 25° C. The catalyst is filtered through a Celite 545 pellet and washed with 2 lots of 100 cm3 of methanol. The filtrate is then concentrated under reduced pressure (5 kPa). 7.7 g of methyl 7-amino-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxylate are obtained in the form of a light green powder.

1. filtrationThe catalyst is filtered through a Celite 545 pellet
2. washwashed with 2 lots of 100 cm3 of methanol
3. concentrationThe filtrate is then concentrated under reduced pressure (5 kPa)