反应详情

5 g of 2-(2-bromophenyl)ethanamine and 10 g of potassium carbonate in 30 cm3 of anhydrous tetrahydrofuran are stirred under an inert atmosphere at a temperature close to 10° C. 2.5 cm3 of methyl chlorocarbonate in solution in 10 cm3 of tetrahydrofuran are poured into the reaction mixture. After returning to a temperature close to 20° C., the reaction mixture is heated for 2 h at the reflux of the solvent. The potassium carbonate is filtered and washed with tetrahydrofuran. The filtrate is concentrated using a rotary evaporator under reduced pressure (5 kPa). 3.43 g of methyl[2-(2-bromophenyl)ethyl]carbamate are obtained in the form of a colorless thick oil

1. customclose to 10° C
2. customclose to 20° C.
3. temperaturethe reaction mixture is heated for 2 h at the
4. temperaturereflux of the solvent
5. filtrationThe potassium carbonate is filtered
6. washwashed with tetrahydrofuran
7. concentrationThe filtrate is concentrated
8. customa rotary evaporator under reduced pressure (5 kPa)