反应详情

To a mixture of methyl 2-(2,4-dichlorobenzylamino)-4-(trifluoromethyl)pyrimidine-5-carboxylate (443 mg) and ethanol (7 mL) was added a solution of potassium hydroxide (200 mg) in ethanol (4 mL), and the mixture was stirred under heating with reflux for 5 hours. The reaction liquid was concentrated under reduced pressure, water (70 mL) was added to the residue, and the liquid property was made acidic (pH 1) with concentrated hydrochloric acid. The product was extracted with ethyl acetate (200 mL) twice, and then the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to obtain 2-(2,4-dichlorobenzylamino)-4-(trifluoromethyl)pyrimidine-5-carboxylic acid (411 mg) as a colorless powder.

1. temperatureunder heating
2. temperaturewith reflux for 5 hours
3. customThe reaction liquid
4. concentrationwas concentrated under reduced pressure, water (70 mL)
5. additionwas added to the residue
6. extractionThe product was extracted with ethyl acetate (200 mL) twice
7. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
8. customThe solvent was evaporated under reduced pressure