Hydrochloric Acid → HCID 86644021, compound

Participants

Reaction Steps

202 mg of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-[1-(4-fluorophenyl)ethyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide are dissolved in a mixture containing ethyl ether and a few drops of methanol at a temperature close to 20° C. 5 cm3 of a 1M solution of hydrochloric acid in ethyl ether are added. The reaction mixture is concentrated using a rotary evaporator under reduced pressure (5 kPa). The solid obtained is triturated in diisopropyl ether, filtered and dried. 206 mg of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-[1-(4-fluorophenyl)ethyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride (1:1) are obtained in the form of an amorphous white solid.

Provenance & Evidence