Hydrochloric Acid → HCID 25206608, compound

Participants

Reaction Conditions

Reaction Steps

300 mg of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-7-[(methylsulfonyl)amino]-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide are dissolved in 10 cm3 of ethyl ether at a temperature close to 20° C. 0.4 cm3 of a 4N solution of hydrochloric acid in dioxane is added while stirring at a temperature of 20° C. The reaction mixture precipitates. The solid is washed with three lots of 5 cm3 of isopropyl ether and dried under vacuum at a temperature of 50° C. 280 mg of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-7-[(methylsulfonyl)amino]-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride (1:1) are obtained in the form of a white powder.

Provenance & Evidence