Hydrochloric Acid → 2-[(1-Methylpiperidin-4-yl)amino]-4-(trifluoromethyl)pyrimidine-5-carboxylic acid hydrochloride

Participants

Reaction Steps

A mixture of methyl 2-[(1-methylpiperidin-4-yl)amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate (322 mg) and 6 M hydrochloric acid (3 mL) was stirred for 31.5 hours under heating with reflux. The reaction liquid was concentrated under reduced pressure, and the residue was solidified from a mixed solvent of diisopropyl ether and ethyl acetate, and then the obtained solid was washed with ethyl acetate to obtain 2-[(1-methylpiperidin-4-yl)-amino]-4-(trifluoromethyl)pyrimidine-5-carboxylic acid hydrochloride (297 mg) as a colorless powder.

Provenance & Evidence