Hydrochloric Acid → HCID 25206779, compound

Participants

Reaction Conditions

Reaction Steps

119 mg of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-7-(3-cyanophenyl)-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide are dissolved in 5 cm3 of ethyl ether. 0.3 cm3 of a 2N solution of hydrochloric acid in ethyl ether is added while stirring at a temperature of 20° C. The precipitate formed is filtered and dried under vacuum at a temperature of 35° C. 89 mg of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-7-(3-cyanophenyl)-1-oxo-2-(1-propylbutyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride (1:1) are obtained in the form of a white powder.

Provenance & Evidence