HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-(4-(6-Cyano-7-(2-methoxyethoxy)-4-quinolyl)oxyphenyl)-N-(3-(methylsulfonyl)phenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Phenyl 3-methylsulfonylphenylcarbamate | HCID 22936234 | — |
| Reactant | 4-(4-Aminophenoxy)-6-cyano-7-(2-methoxyethoxy)quinoline | HCID 22936506 | — |
| Product | N-(4-(6-Cyano-7-(2-methoxyethoxy)-4-quinolyl)oxyphenyl)-N-(3-(methylsulfonyl)phenyl)urea | HCID 67203366 | 75.6% |
Reaction Steps
Diisopropylethylamine (0.057 ml, 0.328 mmol) and phenyl N-[3-(methylsulfonyl)phenyl]carbamate (96 mg, 0.328 mmol) were reacted with 4-(4-aminophenoxy)-7-(2-methoxyethoxy)-6-cyanoquinoline (100 mg, 0.298 mmol), and the title compound (120 mg, 0.225 mmol, 75.6%) was obtained as white crystals by the same procedure as in Example 34.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08372981B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-159bd19b60dd488d8c0e3178e9b69c3f |
| Source note | uspto-grants-2013_02 |