Acetonitrile → HCID 58930961, compound

HRID 387727Notes

Reaction equation

HRID 387727 reaction equation
[NH2:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[C:8]3[C:15]([CH3:16])=[C:14]([CH3:17])[NH:13][C:9]=3[N:10]=[CH:11][N:12]=2)=[CH:4][CH:3]=1.C(#N)C.[F:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]=[C:31]=[O:32])=[CH:26][CH:25]=1>C1(C)C=CC=CC=1>[CH3:16][C:15]1[C:8]2[C:7]([O:6][C:5]3[CH:18]=[CH:19][C:2]([NH:1][C:31]([NH:30][C:27]4[CH:28]=[CH:29][C:24]([F:23])=[CH:25][CH:26]=4)=[O:32])=[CH:3][CH:4]=3)=[N:12][CH:11]=[N:10][C:9]=2[NH:13][C:14]=1[CH3:17]

Participants

5

Reactant 3

HCID 6342AcetonitrileHCID 709554-Fluorophenyl isocyanateHCID 58931289HCID 58931289, compound

Product 1

HCID 58930961HCID 58930961, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

4-(4-Aminophenoxy)-5,6-dimethyl-7H-pyrrolo[2,3-d]-pyrimidine was dissolved in toluene (16 mg) (0.8 ml) and acetonitrile (0.5 ml) under reflux, and then 4-fluorophenyl isocyanate (7.9 μM) was added. The mixture was stirred for 1 hour and returned to room temperature, and then the reaction system was concentrated, diethyl ether was added to the residue, and the resulting crystals were filtered out. The crystals were washed with diethyl ether to obtain the title compound (5 mg).

Workup

  1. customreturned to room temperature
  2. concentrationthe reaction system was concentrated
  3. additiondiethyl ether was added to the residue
  4. filtrationthe resulting crystals were filtered out
  5. washThe crystals were washed with diethyl ether

Sources & evidence

ORD record
ord-d309d47df73748ff8e236fbb267dfbda
Source dataset
uspto-grants-2013_02
Patent number
US08372981B2

Reaction notes

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