HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N-(3-(6,7-dimethoxyquinolin-4-yloxy)propyl)phthalimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-3-Bromopropylphthalimide | HCID 21611 | — |
| Reactant | DMF dimethylformamide | HCID 17824068 | — |
| Reactant | HCID 178486804 | HCID 178486804 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(3-(6,7-dimethoxyquinolin-4-yloxy)propyl)phthalimide | HCID 22936492 | 14.4% |
Reaction Steps
6,7-Dimethoxy-4-hydroxyquinoline (4.0 g, 19.5 mM), N-(3-bromopropyl)phthalimide (5.8 g, 21.5 mM), potassium carbonate (5.4 g, 39 mM) and DMF dimethylformamide (20 ml) were stirred at 60° C. for 1.5 hours. Water, ethyl acetate and tetrahydrofuran were added to the reaction solution for extraction. The solid which precipitated after standing for a period was filtered out to obtain N-(3-(6,7-dimethoxyquinolin-4-yloxy)propyl)phthalimide (1.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08372981B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-3c52d6157410407d814006309460fd28 |
| Source note | uspto-grants-2013_02 |