참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Chloromethyl-1-methylpiperidinium chloride | HCID 106690 | — |
| 반응물 | HCID 136331047 | HCID 136331047 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 22936564 | HCID 22936564 | 3.9% |
반응 단계
After dissolving 6-cyano-4-(4-(4-fluoroanilinocarbonyl)amino-3-fluorophenoxy)quinolin-7-ol sodium salt (222 mg), potassium carbonate (162 mg) and 3-chloromethyl-1-methylpiperidine hydrochloride (86 mg) in dimethylformamide (1.7 ml) and stirring the mixture overnight at 70-80° C., water was added, and extraction was performed with a tetrahydrofuran and ethyl acetate mixed solvent prior to concentration under reduced pressure and purification of the residue with NH Silica (Fuji Silicia Chemical). The obtained solid was washed with ether and dried to obtain the title compound (10 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08372981B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_02 |
|---|
| ORD ID | ord-34859ea23bcf4fbc905239983983f68a |
|---|
| 출처 메모 | uspto-grants-2013_02 |
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