Dimethylformamide → HCID 67205335, compound

Participants

Reaction Steps

After adding 1 ml of dimethylformamide, 47 μl of triethylamine, 18.5 μl of diphenylphosphoryl azide and 8.2 μl of 1-methylpiperazine to 12 mg of the 4-{4-[3-(4-fluorophenyl)ureido]phenoxy)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid synthesized in Example 164, the mixture was stirred overnight at room temperature. Water was added, and the mixture was subjected to liquid separation and extraction with an ethyl acetate-tetrahydrofuran mixed solvent and to NH silica gel column chromatography (ethyl acetate-methanol) to obtain 27 mg of the title compound.

Provenance & Evidence