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Dimethylformamide → 2-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]sulfanyl}-5-nitrothiophene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Bromo-5-nitrothiophene | HCID 83222 | — |
| 反応物 | 7-(Benzyloxy)-6-methoxy-1,4-dihydro-4-quinolinethione | HCID 22936980 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]sulfanyl}-5-nitrothiophene | HCID 58931211 | 76.9% |
反応手順
7-(Benzyloxy)-6-methoxy-1,4-dihydro-4-quinolinethione (14.3 g), 2-bromo-5-nitrothiophene (10 g), potassium carbonate (9.9 g) and dimethylformamide (150 ml) were stirred together at room temperature for 6 hours. Water was added, and the precipitated solid was filtered out and washed with water and then ethyl acetate to obtain 15.7 g of a yellow powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08372981B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-3a5cfc8cecb24524a3949a1aad538921 |
| 出典メモ | uspto-grants-2013_02 |