HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl cyclopropylcarbamate → {4-[4-(Cyclopropylureido)-3-fluorophenoxy]-7-methoxyquinolin-6-yl]carbamic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl cyclopropylcarbamate | HCID 13648483 | — |
| Reactant | [4-(4-Amino-3-fluorophenoxy)-7-methoxyquinolin-6-yl]carbamic acid benzyl ester | HCID 58931409 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | {4-[4-(Cyclopropylureido)-3-fluorophenoxy]-7-methoxyquinolin-6-yl]carbamic acid benzyl ester | HCID 58931295 | 9.2% |
Reaction Steps
[4-(4-Amino-3-fluorophenoxy)-7-methoxyquinolin-6-yl]carbamic acid benzyl ester (100 mg) and cyclopropylcarbamic acid phenyl ester (64 mg) were heated and stirred in dimethylsulfoxide (0.7 ml) at 85° C. for 5 hours and 40 minutes, in the same manner as Example 224, to obtain the title compound (11 mg) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08372981B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-29c6311b35814728bcc3bf5a15fd4f7e |
| Source note | uspto-grants-2013_02 |