HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dibromopropane → n-(4-((7-(3-Bromopropoxy)-6-cyano-4-quinolyl)oxy)-2-chlorophenyl)-n'-cyclopropylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dibromopropane | HCID 8001 | — |
| Reactant | n-(4-(6-Cyano-7-hydroxy-4-quinolyl)oxy-2-chlorophenyl)-n'-cyclopropylurea | HCID 135829385 | — |
| Product | n-(4-((7-(3-Bromopropoxy)-6-cyano-4-quinolyl)oxy)-2-chlorophenyl)-n'-cyclopropylurea | HCID 22936714 | 15.6% |
Reaction Steps
The title compound (129 mg, 0.250 mmol, 15.6%) was obtained as light brown crystals from an N-(4-(6-cyano-7-hydroxy-4-quinolyl)oxy-2-chlorophenyl)-N′-cyclopropylurea crude product (500 mg, 1.60 mmol) and 1,3-dibromopropane, by the same procedure as in Example 7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08372981B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-82f54496a5bd4dbba2a77e321a67340a |
| Source note | uspto-grants-2013_02 |